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All posts for the day February 3rd, 2022
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I’m trying to keep track So we’re killing ISIS again now? Haven’t been paying enough attention to know if we fighting them this year or arming them or both
OMG! Even Fox News has this one right!
Here‘s what I think, and what I’m hearing from Saskatchewan people.
Conclusions: Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8088823/
Pierre Kory, MD,1,*Gianfranco Umberto Meduri, MD,2Joseph Varon, MD,3Jose Iglesias, DO,4 and Paul E. Marik, MD5Author information
Copyright and License informationDisclaimer
See letter “Ivermectin, A Reanalysis of the Data” in Am J Ther, volume 28 on page e579.This article has been corrected.
This article has been cited by other articles in PMC.Go to:
Background:
After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel and repurposed therapeutic agents were used empirically and studied within clinical trials.
Areas of Uncertainty:
The majority of trialed agents have failed to provide reproducible, definitive proof of efficacy in reducing the mortality of COVID-19 with the exception of corticosteroids in moderate to severe disease. Recently, evidence has emerged that the oral antiparasitic agent ivermectin exhibits numerous antiviral and anti-inflammatory mechanisms with trial results reporting significant outcome benefits. Given some have not passed peer review, several expert groups including Unitaid/World Health Organization have undertaken a systematic global effort to contact all active trial investigators to rapidly gather the data needed to grade and perform meta-analyses.
Data Sources:
Data were sourced from published peer-reviewed studies, manuscripts posted to preprint servers, expert meta-analyses, and numerous epidemiological analyses of regions with ivermectin distribution campaigns.
Therapeutic Advances:
A large majority of randomized and observational controlled trials of ivermectin are reporting repeated, large magnitude improvements in clinical outcomes. Numerous prophylaxis trials demonstrate that regular ivermectin use leads to large reductions in transmission. Multiple, large “natural experiments” occurred in regions that initiated “ivermectin distribution” campaigns followed by tight, reproducible, temporally associated decreases in case counts and case fatality rates compared with nearby regions without such campaigns.
Continue:
WEDNESDAY, FEB 02, 2022
By Michael Every of Rabobank
Choosing wallpaper during the Blitz
We really are back to elements of the 1920s and 1930s in tandem, it seems, even if markets still don’t grasp that underlying reality. Actually, markets are starting to grasp the 20s parallel when it comes to social unrest, political breakdowns where political parties are either compromised or irrelevant, and popular ‘movements’ emerge spontaneously instead (luckily so far absent charismatic leaders). Indeed, Wall Street appears to be all in — by which I mean exacerbating — it. The smart money also sees the end parallel of the everything bubble and a Fed raising rates anyway. Some focus on a 30s background where Russian President Putin says on European security: “It’s already clear…that Russia’s principal concerns were ignored” and that the West is using Ukraine as a “tool to hinder Russia”.
There seems no way to bridge the fundamental differences in interpretations of the 1975 Helsinki European security agreement that says all states are sovereign and free to decide which defence alliance they want to join, and that no state should join an alliance seen as a threat by another. Which clause has primacy? The former, if you view NATO as defensive. The latter, if you see NATO as offensive.
As in the 1920s/30s, you also get passionate, polarized views on who is to blame. There are those who see Putin as Hitler and Ukraine as the Sudetenland – or Poland. There are those who see the ‘US Deep State’ driving things. And both can be true, which just makes matters worse.
Meanwhile, the scandal-plagued UK government (this time it is about prosecco, not cake) and its Polish and Ukrainian counterparts are to sign a trilateral defence treaty. Of course, such defense pacts are not new – back in September 1996 the same trio were saying the same thing. Yet the UK guaranteeing not just Ukraine’s but Poland’s border…are history, and the UK government, slurring old lyrics, rhyming or repeating themselves?
There is also pressure building in the Balkans: Bosnia, Kosovo, Albania, Serbia, Montenegro, and North Macedonia –maybe even EU member Bulgaria– are all in a pot Russia is helping to stir. Its Foreign Minister just stated he does not accept that Montenegro and North Macedonia should be NATO members when they already are.
Yet NATO member Hungary’s PM just visited Moscow, and the Russian Ministry of Foreign Affairs oozed: “Hungary has invariably confirmed its reputation as a reliable partner in the transit of Russian fuels. Naturally, we are willing to build up mutually advantageous cooperation in this area.” In other words, don’t expect any EU energy sanctions if Budapest has a veto? Yet that means the West has no pressure point against Russia except the military, where it is outgunned.
Meanwhile, Russia just banned the export of ammonium nitrate for two months (while Lithuania has fully blocked the rail shipment of potash from Belarus). The potential upside impact on fertilizer prices in Europe should be obvious. So should the fact that Russia clearly understands the geopolitical and geoeconomic pressure points that *it* controls. They can see the US does not want to raise rates but has to. They can also see that they can force inflation far higher, inflicting huge economic pain, even if they take some too. That is how economic wars work. Are we ready to fight one, or are we going to redraw borders to avoid one?
The scale of what is happening over markets’ heads –and the naval-gazing drivel on Bloomberg this morning– is summarized by former Portuguese politician Bruno Maçães in a Time magazine article, “What Happens Next in Ukraine Could Change Europe Forever”. In it, he notes: “The Russian television anchor Dmitry Kiselyov, known as a reliable Kremlin mouthpiece, explained on air during the past weekend that the current crisis is not about Ukraine: ‘The scale is much bigger.’” I concur: which is why I called it a metacrisis.
Maçães adds another line I have been stressing since 2017: “We no longer live in the old liberal order where rules must be enforced, and violators punished. We live in a new order where power must be balanced with power.” And the EU has no such power! If only its preparations had been made as far back as 2017 when ‘The Great Game of Global Trade’ came out.
As such, Maçães argues “The US must reflect on whether it can afford to reduce its presence in Europe before a proper counterweight to Russia has been created in Brussels. The pivot to Asia may need to wait for a solution to the European crisis. As for Europeans, they need to quickly prepare themselves for a new world, where their sovereignty and security may well be at stake.” Except the dynamic in the US is not moving in that direction. Asia is the priority, regardless.
He continues: “The existing order is starting to buckle, and Washington needs to decide how best to replace it with new arrangements. Does it prefer to reach a grand bargain with Moscow whereby the two powers divide Europe among themselves? Or does it prefer to encourage and support the development of a new European pole capable of balancing Russian power?” He is literally talking about a new partition of Europe into spheres of interest: and European markets are looking at what the ECB will do on Thursday. I can tell you ECB rates are unlikely to rise ahead –what’s new there?– but I can’t tell you what the geography and political architecture of the EU where you borrow that money will look like in 5 years. Keeping a focus just on the screens at times like this is akin to happily choosing new wallpaper during the London Blitz.
Maçães concludes: “To me the choice seems an obvious one, but what is frustrating about the current crisis is how we keep avoiding the larger questions of political order. By hesitating we allow others to assume the role of reformers and innovators. Eurasia, the supercontinent, is being reshaped before our eyes.” Yes – as the EU is talking about its usual soft, cuddly 2005-vintage talking points. But don’t worry – the Conference on the Future of Europe is waiting for your input! The website hasn’t added Russian as a language option yet.
We do perhaps see key movement from Germany – not against Russia, but China. It is reported Chancellor Scholz is to officially prioritize engagement with democratic partners in the Indo-Pacific instead of China, will travel to Japan to hold consultations, and fully supports Lithuania against Chinese coercion; hawkish Foreign Minister Baerbock will be allowed to champion initiatives against China; and German diplomats in the Indo-Pacific are “being encouraged to push the envelope and resist old habits to self-censor” when developing new China strategies. Obviously, this will greatly exacerbate EU-China economic tensions – but there is no military component. So, are these steps a quid pro quo to try to ensure the US stays committed to the EU’s defence, rather than –as Maçães says– carving it up with Russia and looking to Asia?
Perhaps. Yet if you have decided to turn your economy into a weapon, as the EU thinks it has, then using it involves taking hits: armies take damage in war – economies take damage during economic wars. That is how economic wars work. The US is most unlikely to change its mind on strategic options vis-à-vis Asia unless the EU is prepared to take pain on the sanctions front to send Russia a message. Even then, what to do about Hungary, should consensus be required?
Let’s all go and look at wallpaper patterns instead, why not?
Feb 2, 2022
Wei-Bin Shen, James Logue, Penghua Yang, Lauren Baracco, Montasir Elahi, E. Albert Reece, BingBing Wang, Ling Li, Thomas Blanchard, View ORCID ProfileZhe Han, Matthew Frieman, View ORCID ProfileRobert A. Rissman, Peixin Yangdoi: https://doi.org/10.1101/2022.01.31.478476
This article is a preprint and has not been certified by peer review [what does this mean?]
Abstract
Major cell entry factors of SARS-CoV-2 are present in neurons; however, the neurotropism of SARS-CoV-2 and the phenotypes of infected neurons are still unclear. Acute neurological disorders occur in many patients, and one-third of COVID-19 survivors suffer from brain diseases. Here, we show that SARS-CoV-2 invades the brains of five patients with COVID-19 and Alzheimers, autism, frontotemporal dementia or no underlying condition by infecting neurons and other cells in the cortex. SARS-CoV-2 induces or enhances Alzheimers-like neuropathology with manifestations of beta-amyloid aggregation and plaque formation, tauopathy, neuroinflammation and cell death. SARS-CoV-2 infects mature but not immature neurons derived from inducible pluripotent stem cells from healthy and Alzheimers individuals through its receptor ACE2 and facilitator neuropilin-1. SARS-CoV-2 triggers Alzheimers-like gene programs in healthy neurons and exacerbates Alzheimers neuropathology. A gene signature defined as an Alzheimers infectious etiology is identified through SARS-CoV-2 infection, and silencing the top three downregulated genes in human primary neurons recapitulates the neurodegenerative phenotypes of SARS-CoV-2. Thus, SARS-CoV-2 invades the brain and activates an Alzheimers-like program.
Competing Interest Statement
The authors have declared no competing interest.
Paper in collection COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv
Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.